The International Society of Paediatric Oncology’s (SIOP) Paediatric Oncology in Developing Countries (PODC) group – SIOP PODC, comprises several working groups comprising experts in the field of paediatric oncology. One of these groups is dedicated to producing adapted treatment guidelines – for the treatment of various childhood malignancies in low income settings.

Through this group, the Wilms tumour treatment guidelines for a Setting 1 were developed. Setting 1 indicates that only the minimal requirements for treatment with curative intent are possible.

Following publication of the Setting 1 guidelines for Wilms tumour management, a steering group of clinicians was formed to develop a detailed treatment and study protocol for this malignancy. The steering group was formed of African and European doctors, led by Dr. Trijn Israels. The finished protocol was introduced into a multi-country sub-Saharan collaboration project in 2014.

The participating centres for the start of the collaboration were in Malawi, Ghana, Cameroon and Uganda. Representatives from the centres were present in the initial steering committee, all of whom are excellent clinicians who are dedicated to treating children with cancer in extremely difficult conditions.



Children with common and curable cancers in sub-Saharan Africa will achieve survival rates greater than 60-70% in line with the vision of the Global Initiative for Childhood Cancer, launched by the World Health Organisation (WHO).



To improve survival for children with common and curable cancers in sub-Saharan Africa by reducing treatment related deaths, reducing abandonment of treatment and by using locally appropriate treatment guidelines.



– To improve care and survival of children (with Wilms tumour) in Africa

– To facilitate the development of a regional network for childhood cancer

– To strengthen the local multi-disciplinary teams

– Increase survival of common and curable cancers to >60%

– Decrease abandonment <10%

– Decrease death during treatment <10%

– Develop, implement and assess locally appropriate treatment guidelines