The Childhood Cancer Survivor Study (CCSS) is an NCI-funded resource for the study of long-term survivors of cancer diagnosed during childhood and adolescence. Details regarding the cohort are available at https://ccss.stjude.org/. Members of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute and CCSS investigators collaborated to conduct a genome-wide association study, initially intended to study the role of genetic susceptibility in the development of subsequent neoplasms as well as first primary childhood cancers using samples from the CCSS Biorepository. Genotyping was conducted for 5739 childhood cancer survivors diagnosed 1970-1986 (5324 are of European ancestry) using the Illumina HumanOmni5Exome microarray, with over 4.1 million loci passing quality control thresholds (based on locus and sample missing rates, sample heterozygosity, and sex discrepancies).
The CCSS leadership is now broadening the scope of this initiative to study the role of genetic susceptibility in the development of non-malignant treatment-related outcomes in cancer survivors. Accordingly, CCSS is announcing a request for proposals to collaborate with CCSS and NCI investigators in the use of existing genome-wide association study (GWAS) data and corresponding outcomes-related data to address innovative research questions relating to potential genetic contributions to risk for non-malignant treatment-related outcomes. Requests will be accepted on an ongoing basis and will be reviewed three times per year, in February, June and October (cut-off for receipt of applications February 1st, June 1st, October 1st).
Details regarding the application process as well as the application for data access can be found at