Since PARC-funded project initiation, major foundational components have been successfully established. Case Report Forms (CRFs) were fully developed and tested in REDCap, and National Bioethics Committee approval was secured in September 2025, enabling formal registry operations. Three data managers were hired in alignment with the initial enrollment of four pilot centers, with plans to recruit two additional staff as the network expands. Financial implementation is proceeding appropriately, with 13.69% of the grant budget spent during the first six months through gradual, planned expenditures.

Substantial progress has been made in center engagement, training, and capacity building. Four collaborating centers were enrolled during the reporting period, all of which received IRB approvals with facilitation from the PSPO central office. A comprehensive training curriculum for data managers and principal investigators was developed and delivered through a combination of a two-day in-person workshop and a 12-module virtual program. Specialized orientation for principal investigators ensured alignment with registry protocols and data standards, while development of Virtual Learning Environment modules is ongoing.

Patient enrollment and data quality assurance activities were successfully launched on October 1, 2025. All four participating centers exceeded the target of registering at least 10% of their expected annual cases within three months. Monthly remote data quality reviews are being conducted, supported by real-time duplication screening and validation checks, and feedback has been routinely shared with sites. Overall, the project is on track, early milestones have been met or exceeded, and no major barriers are anticipated to achieving future objectives.