The GHN Adapted Therapy Regimen WG promotes the development of universal templates and pragmatic guidelines for the treatment of Childhood Cancer in the according to the specific setting of pediatric care. The settings 0, 1, 2, 3 and 4, are adjudicated a framework describing the elements that these guidelines should contain.

An Adapted Treatment Regimen WG Symposium took place at SIOP Toronto 2014 with the aim of bringing together the experiences and outcomes of low and low-middle income countries, and a first view of the Framework of Adapted Therapies. Our main goal is to partner and advocate with healthcare teams world-wide to improve care of children with cancer.

The GHN Adapted-Therapy Regimen WG has worked on following five ATRs:

• Hepatoblastoma
• Non-CNS Germ cell tumor
• CNS Germ cell tumor
• Nasopharyngeal carcinoma

All groups had significant advances; however, CNS Germ Cell tumor, hepatoblastoma and nasopharyngeal carcinoma were sent to the Scientific committee for review. We expect to publish a new supplement on PBC journal including the above plus Hodgkin lymphoma. The non-CNS Germ Cell tumor and rhabdomyosarcoma still have to be submitted to Scientific committee. ATR on AML has been published very recently in PBC (https://onlinelibrary.wiley.com/doi/full/10.1002/pbc.28087)