THE COLLABORATIVE WILMS TUMOUR PROJECT
The project is implementing a SIOP PODC adapted treatment guideline for Wilms tumour in several centres in sub-Saharan Africa. This is done as a multi centre prospective clinical trial with uniform outcome evaluation. The project started in 2014. More than 300 patients have been included and treated. End of treatment survival without evidence of disease increased from 52% to 68%. Death during treatment decreased from 21% to 13% and abandonment of treatment from 23% to 13%.
To improve survival for children with common and curable cancers in Sub Saharan Africa by reducing treatment related deaths, reducing abandonment of treatment and by using locally appropriate treatment guidelines.
Children with common and curable cancers in sub -Saharan Africa will achieve survival rates greater than 60-70% in line with the vision of the Global Initiative for Childhood Cancer, launched by the World Health Organisation (WHO).
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The Wilms tumour collaboration project is currently running in 8 centres in 5 sub-Saharan African countries. All participating centres have established Wilms tumour treatment. All participating centres have established Wilms tumour treatment.
A detailed treatment and study protocol was developed in March 2013 at a working group meeting in Malawi, following SIOP PODC guidelines. Collaborative Wilms Tumour Africa Treatment Guidelines Phase II are currently being updated, and will be launched in 2020.