SIOP, SIOP Asia and SIOP Europe express their deep concern for the well-being of children, as well as their families amidst the ongoing conflict in southern Israel and the Gaza Strip. Children and adolescents with cancer may be placed under a compounded direct risk due to their life-threatening illness and the disruptive conflict during such crises. We hope for a swift resolution to this volatile conflict so that the affected populations can regain stability, peace and above all, safety.